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International Journal of Pediatrics and Neonatology

Vol. 6, Issue 2, Part D (2024)

A study of common complications of beta thalassemia major in children in a tertiary care hospital of south Rajasthan

Author(s):

Pragyee Dhingra and Bhavya Verma

Abstract:

Aim: Ineffective erythropoiesis and chronic hemolysis culminate in numerous clinical complications in thalassemia patients. Beta-Thalassemia major patients experience manifestations of severe anemia, growth retardation, gonadal failure, splenomegaly, iron overload, and skeletal deformities. The study aimed to access the various complications in children with beta-thalassemia major.
Materials and Methods: 226 patients with beta thalassemia major were enrolled in the study after taking parental consent. Blood investigations such as complete blood counts, liver function and renal function tests were done. Investigations for endocrine functions like thyroid and HbA1C were done. Anthropometric measures and sexual maturation using tanner staging were noted.
Result: Out of 226 children of beta thalassemia major, males were 51.3% (116) and females were 48.7% (110). There was no significant gender difference in thalessemia patients in our study. The mean BMI was 16.61 kg/m2 with SD 5.34 and 16.26 kg/m2 with SD 2.91 for age group of 5-10 years and 11-18 years respectively. BMI of both the age group was almost similar showing increased incidence of under nutrition as the disease and its complication evolutes. There was significant growth delay present in thalassemia patient (p value <0.0001 using Chi Square test with CI: 55.14%-72.95%). 
Conclusion: Beta- thalassemia is one of the most common inherited blood disorder requiring frequent blood transfusion. There are various complications associated with beta- thalassemia major. Complications can arise due to ineffective erythropoiesis and chronic hemolysis or it can be due to transfusion related complications. In this study, we observed high ferritin levels as a result of chronic blood transfusion in thalassemic patients. Also, BMI of these patients indicated under nutrition and there was a significant growth delay present in thalassemic patients.
 

Pages: 255-259  |  56 Views  18 Downloads


International Journal of Pediatrics and Neonatology
How to cite this article:
Pragyee Dhingra and Bhavya Verma. A study of common complications of beta thalassemia major in children in a tertiary care hospital of south Rajasthan. Int. J. Pediatr. Neonatology 2024;6(2):255-259. DOI: 10.33545/26648350.2024.v6.i2d.109
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