Vol. 6, Issue 2, Part C (2024)

Introduction: Haemophilia affects a large number of people all over the world, yet very little is known about the clinical manifestations and diagnostic protocols of the condition in areas with limited access to resources in developing countries. Understanding the clinical spectrum and diagnostic approach will help with the design of measures to address the situation in these places. The primary objective of this study was to find out the clinicopathological parameters of haemophiliac patients.

Materials and Methods: This prospective study was done in Dhaka Shishu Hospital from July 2020 to July 2024. Total 110 Hemophiia patients were included in the study. After admission detailed history, physical examination and laboratory investigations like CBC, Blood grouping and Rh typing,BT, PT, APTT, Factor VIII and IX assay, HBs Ag, HCV were done and result were recorded in questionnaire sheet. Informed written consent were taken from parents. Data were analysed by SPSS version 24. P value <0.05% were taken as significant.

Results: Out of a total of 110 cases over the period of four years, 85.45% were classified as haemophilia A and 14.55% of cases were diagnosed as haemophilia B. In terms of the severity of the disease, 45.45% were classified as severe, 36.36% as moderate, and 18.18% as mild. Joint bleeding was the first and most typical clinical manifestation of the disease, accounting for 36.36% of cases, followed by ecchymosis (14.56%), post-traumatic bleeding (4.55%), epistaxis (4.55%), and gum bleeding (4.55%). 2.73% of patients had a positive screening test for the hepatitis C virus, followed by 1.81% for hepatitis B surface antigen.

Conclusion: In the presence of joint bleeding, ecchymosis, and post-traumatic bleeding in an otherwise healthy male individual, a clinician should be alerted to the possibility that the patient has haemophilia and should request a work-up for the bleeding disorder.