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International Journal of Pediatrics and Neonatology

Vol. 6, Issue 1, Part A (2024)

Clinical significance of ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome

Author(s):

Shaimaa Eissa Ammar, Mohamed Shokry Elharoun, Noran Talaat Aboelkhair and Ghada Mohamed El-Mashad

Abstract:

Background: Elevated IMA levels are a valuable biochemical indicator for diagnosing myocardial ischemia. Additionally, they are associated with several clinical diseases involving type 2 diabetes, metabolic syndrome, cancer, as well as chronic kidney disease. 
The aim of this work was to investigate clinical significance of IMA levels as an oxidative stress’ marker among SSNS children throughout remission as well as relapse. 
Methods: Our cross sectional descriptive and analytical study involved 90 cases whose ages are older than 2 years, both genders, developing SSNS who were subdivided into two subgroups: [Group AI: Relapse and Group AII: remission and 90 children apparently healthy with normal kidney functions being matched with cases regarding age, sex and socioeconomic status. 
Results: IMA exhibited a significant positive association with SBP, DBP, serum cholesterol as well as urinary protein creatinine ratio while negative correlation with serum albumin in the cases group. Serum IMA can significantly predict oxidative stress in children with SSNS at cut-off >95 addressing 100% sensitivity, specificity, PPV and NPV. Cases with relapse exhibited greater IMA level as opposed to others with remission. IMA exhibited significantly greater values within cases group as opposed to controls (p<0.001). 
Conclusions: Ischemia modified albumin might be utilized as non-invasive biomarker while diagnosing NS among children, being higher in level in those cases. Ischemia modified albumin could also be used as biomarker for identifying the course of the disease, being higher in cases with disease relapse.
 

Pages: 41-46  |  54 Views  23 Downloads


International Journal of Pediatrics and Neonatology
How to cite this article:
Shaimaa Eissa Ammar, Mohamed Shokry Elharoun, Noran Talaat Aboelkhair and Ghada Mohamed El-Mashad. Clinical significance of ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome. Int. J. Pediatr. Neonatology 2024;6(1):41-46. DOI: 10.33545/26648350.2024.v6.i1a.69
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International Journal of Pediatrics and Neonatology